Rifampin induction
WebRifampin also induces Phase II metabolizing enzymes, which are responsible for biotransformations such as glucuronidation and sulfation, as well as the efflux pump p-glycoprotein and other drug transporters. Induction of these enzymes can lead to reduced plasma concentrations of co-administered drugs that are substrates of these enzymes. Webdrugs that cause clinically relevant CYP3A4 induction have been reported, including the antibiotic rifampin and the anticonvulsants phenobarbitone, phenytoin, and carbamazepine (review article by McInnes and Brodie, 1988). Rifampin causes auto-induction because CYP3A4, which it induces, is also responsible for its clearance (Acocella, 1978).
Rifampin induction
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WebDrugs such as rifampin and erythromycin, which are known to be inducers or substrates of cytochrome P-450IIIA, have the potential to alter cyclosporine blood concentrations. The present case shows a multiple drug interaction with cyclosporine. WebFeb 17, 2024 · The use of rifampin warrants increased awareness of possible drug interactions caused by liver enzyme induction. Rifampin should only be used in combination with other antibiotics for S. aureus infections because resistance can develop rapidly with monotherapy. Streptococcus (group A) chronic carriageyes
WebApr 18, 2011 · Rifampin is known to induce multiple enzymes responsible for drug metabolism including cytochrome P450 (CYP)1A2, CYP2C8, CYP2C9, CYP2C19, CYP3A4, and some glucuronidation pathways. In addition, it has been reported to induce the activity of several drug transporters, such as the organic anion transporter and P-glycoprotein. WebJun 16, 2024 · Rifampin is an antibiotic that is used to treat or prevent tuberculosis (TB). Rifampin may also be used to reduce certain bacteria in your nose and throat that could cause meningitis or other infections. Rifampin prevents you from spreading these bacteria to other people, but rifampin will not treat an active meningitis infection.
WebJul 23, 2024 · Rifampin is an antibiotic used to treat several types of bacterial infections. Combined with other intravenous antibiotics, rifampin is the first-line choice for the treatment of Staphylococcal prosthetic joint infections (PJI) in patients undergoing total joint arthroplasty ( Osmon et al., 2013 ). WebRifampin caused a 13-fold induction of testosterone 6beta-hydroxylase (CYP3A12) activity in vitro and up to a 4.5-fold increase in vivo. Treatment of dogs in vivo or dog hepatocytes in vitro with clofibric acid appeared to have no effect on CYP4A activity as determined by the 12-hydroxylation of lauric acid.
WebRifampin is a potent inducer of CYP3A4 in vitro and precipitates numerous drug-drug interactions (DDIs) when coadministered with CYP3A4 substrates. In the current study, we have critically assessed reported rifampin in vitro CYP3A4 induction data in Fa2N-4, HepaRG, and cryopreserved or primary human …
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