WebThe Psychiatric Genetics Consortium (PGC) unites investigators around the world to conduct meta- and mega-analyses of genome-wide data for psychiatric disorders including schizophrenia, bipolar, ADHD, PTSD and autism. Our group is responsible for data production, bringing together over 20,000 samples from more than 60 different sites … WebNov 5, 2024 · Objective: Pharmacogenomic studies of antipsychotics have typically examined effects of individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome-wide association studies (GWAS) can quantify the influence of thousands of common alleles of small effect in a single measure. The authors examined …
Evidence for causal effects of lifetime smoking on risk for …
WebGenome-wide association studies (GWAS) have proved to be a powerful approach for gene discovery in schizophrenia; their findings have important implications not just for our … WebHarnessing the power of 800+ international scientists & 900,000 participants. Since 2007, the PGC has been committed to uncovering the role of genetics in psychiatric … cheap car insurance inglewood ca
Genetics of Schizophrenia: New Findings and Challenges
WebAn initial GWAS of 2681 cases and 2653 controls from the Molecular Genetics of Schizophrenia (MGS) sample by Shi and colleagues found no loci reaching genome-wide significance, yet the meta-analysis of 8008 cases and 19,077 controls identified 7 SZ-associated SNPs on chromosome 6p22.1, which represents the extended major … WebGWAS and meta-analysis. We obtained genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample), which we combined with control datasets obtained from public repositories or through collaboration. The final sample size was 11,260 cases and 24,542 controls (5,220 cases and 18,823 controls not in previous … cut hair with clippers men